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Multi-Chamber Bag Compounding

Easy to mix TPN bag compounding

Multi-chamber bags assist pharmacists in the safe drug compounding of total parenteral nutrition (TPN) solutions.

B. Braun offers a wide range of ready-to-use 3-chamber bags named Nutriflex® Lipid and Nutriflex® Omega*. Our bags with and without omega-3 fatty acids are easy to compound by design. Discover all benefits for pharmacists.
*Names vary from country to country

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3-chamber bag

The bag design

filled 3-Chamber Bag

Color Coding

simplifies differentiation of bag versions and ports

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Practical Information

List of macronutrient and caloric content

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Quick Key Information

Type of lipid emulsion in

  • the bag (Lipofundin® or Lipidem® / Lipoplus®) Administration route
  • (peripheral or / and central venous)
  • With or without electrolytes

/

Advanced Port System

Tamper evident ports with a sterile surface enhance the sense of security. Color coding: Different port colors clearly differentiate between the additive (white cap) and the infusion port (green cap).

/

Oxygen Indicator

Do not use the bag if the oxygen indicator is pink. Use the bag only if the oxygen indicator is yellow.1-4, 23-26

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Extended product range

A 3-chamber bag filled with liquid on the left side, with the products it is designed to replace on the right.

1| Medium Chain Triglycerides: Source of readily available energy

2| Soya Bean Oil: Covers essential fatty acid requirements

3| Omega-3-acid Triglycerides: From fish oil for the delivery of EPA and DHA

A selection of fruits and beans

Nutriflex® Lipid

with Lipofundin® (MCT/LCT) as lipid component.1-4 Licensed for use in children older than 2 years old, adolescents and adults.Lipofundin® Medium-chain triglycerides / long-chain triglycerides (MCT/LCT) can be liver-protective5-10, improve lung function11-21 and may reduce morbidity and mortality.22

A selection of various fruits and beans

Nutriflex® Omega with Lipidem® / Lipoplus®

(MCT/LCT/Omega-3-acid Triglycerides) as lipi component.4, 23-26 For the use in adults. Lipidem® / Lipoplus® can reduce the risks of nosocomial infections27, reduce hospital length of stay29-30 and may improve O2 gas exchange.28

with Lipofundin® (MCT/LCT) as lipid component.1-4 Licensed for use in children older than 2 years old, adolescents and adults.Lipofundin® Medium-chain triglycerides / long-chain triglycerides (MCT/LCT) can be liver-protective5-10, improve lung function11-21 and may reduce morbidity and mortality.22

Compatibility check made easy

With our compatibility software EasyComp you can check compatibility and stability of a regimen before you prepare the mixture. EasyComp allows corrective measures if compatibility is not confirmed.

More information on parenteral nutrition compounding

Nutriflex®

3-chamber bags for parenteral nutrition

Multi-chamber bags for parenteral nutrition are used as synonym for standardized, commercially available ready to use products with two or three chambers.

Get more product information
A female health care professional holds a 3-chamber bag

Guidelines and Asset Tools

Parenteral Nutrition
Discover our related products
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Nutrition Compounding

Preparation of macro- and micronutrients in different combinations and volume ranges can be achieved through manual or automated compounding. Find out how we help you achieve this.
More about tpn compounding

References

  1. SmPC Nutriflex® Lipid 32/64 peri, Status of latest information: April 2020.
  2. SmPC Nutriflex® Lipid 38 /120 plus, Status of latest information: April 2020.
  3. SmPC Nutriflex® Lipid 56/144 special, Status of latest information: April 2020.
  4. SmPC Nutriflex® Lipid 56/144 special without electrolytes, Status of latest information: April 2020.
  5. Carpentier YA, Siderova V, Bruyns J, and Rubin M. Long-term TPN and liver dysfunction Clinical Nutrition 8 (1989) 31, special supplement.
  6. Kuse, E.R. et al. Hepatic reticuloendothelial function during parenteral nutrition including an MCT/LCT or LCT emulsion after liver transplantation – a double blind study; Transpl. Int. (2002); 15, 272-277.
  7. Lai HS, Chen WJ. Effects of medium and long-chain triacylglycerols in pediatric surgical patients; Nutrition (2000); 16, 401-406.
  8. Dennison AR, Ball M, Hands LJ, Crowe PJ, Watkins RM, Kettlewell M. Total parenteral nutrition using conventional and medium-chain triglycerides: effects on liver function tests, complement, and nitrogen balance; JPEN (1988); 12, 15-19.
  9. Goulet O, Postaire M, De Potter S, Boya I, Jouniaux AM, Bereziat G, Ricour C. Medium-chain triglycerides and long-term parenteral nutrition in children; Nutrition (1992); 8, 333-337.
  10. Rubin M, Harell D, Noar N, Moser A, Wielunski E, Merlob P, Lichtenberg D. Lipid infusion with different triglyceride cores (long-chain versus medium-chain/long-chain triglycerides): effect on plasma lipids and bilirubin binding in premature infants; JPEN (1991); 15, 642-646.
  11. Radermacher P, Santak B, Strohbach H, Schror K, Tarnow J. Fat emulsions containing medium- chain triglycerides in patients with sepsis syndrome: effects on pulmonary hemodynamics and gas exchange; Intensive Care Med (1992); 18, 231-234.
  12. Masclans JR, Iglesia R, Bermejo B, Pico M, Rodriguez-Roisin R, Planas M. Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome; Intensive Care Med (1998); 24, 918-923.
  13. Planas M, Masclans JR, Iglesia R, Porta I, Valls M, Bermejo B. Eicosanoids and fat emulsions in acute respiratory distress syndrome patients; Nutrition (1997); 13, 202-205.
  14. Fiaccadori E, Tortorella G, Gonzi G, Pincolini S, Belli L, Albertini D, Beghi C, Avogar A. Hemodynamic, respiratory, and metabolic effects of medium-chain triglyceride-enriched lipid emulsions following valvular heart surgery; Chest (1994); 106, 1660-1667.
  15. Fiaccadori E, Tortorella G, Gonzi G, Beghi C, Albertini D, Pincolini S, Belli L, Avogaro A. Hemodynamic and respiratory effects of medium-chain and long chain triglyceride fat emulsions: a prospective, randomized study; RINPE (1997); 15, 6-14.
  16. Kourias E, Theodosopoulos T, Datsis A, Vassiliou J, Smyrniotis B. A comparison of the effects of fat emulsions (LCT) and mixture fat emulsions
  17. (LCT + MCT) on cardiorespiratory system in septic patients with respiratory failure (ARDS); 9th European Congress on Intensive Care Medicine (1996); 517-521; Glasgow.
  18. Smirniotis V, Kostopanagiotou G, Vassiliou J, Arkadopoulos N, Vassiliou P, Datsis A, Kourias E. Long-chain versus medium-chain lipids in patients with ARDS: effects on pulmonary haemodynamics and gas exchange; Intensive Care Med (1998); 24, 1029-1033.
  19. Smirniotis VE, Kostopanagiotou GG, Arkadopoulos NF, Theodoraki KA, Kotsis TE, Lambrou AT, Vassiliou JG. Long-chain versus medium-chain lipids in acute pancreatitis complicated by acute respiratory distress syndrome: effects on pulmonary hemodynamics and gas exchange; Clinical Nutrition (2001); 20, 139-143.
  20. Faucher M, Bregeon F, Gainnier M, Thirion X, Auffray JP, Papazian L. Cardiopulmonary effects of lipid emulsions in patients with ARDS; Chest (2003); 124, 285-291.
  21. Marsili I, Iovinelli G, Varrassi G. Parenteral nutrition in COPD patients: long vs. medium-chain triglycerides (MVT); Clinical Nutrition (1992); 11, 45; special supplement.
  22. Milanov S, Milanov M, Georgieva M. Short-term lung metabolic effects of medium-chain triglycerides/long-chain triglycerides-containing lipid emulsions in patients with post-traumatic acute respiratory distress syndrome; Critical Care (2004); 8, 138; supplement 1.
  23. Grau T, Ruiz de Adana C, Zubillaga S, Fuerte S, Girón C. Estudio aleatorio de dos emulsiones grasas diferentes en la nutrición parenteral total del enfermo quirúrgico desnutrido: efecto sobre la morbilidad infecciosa y la mortalidad Nutr Hosp 18 (2003) 159-166.
  24. SmPC Nutriflex® Omega peri, Status of latest information: April 2020.
  25. SmPC Nutriflex® Omega 38 /120 / 40, Status of latest information: April 2020.
  26. SmPC Nutriflex® Omega 56 /144 / 40, Status of latest information: April 2020.
  27. SmPC Nutriflex® Omega special without electrolytes, Status of latest information: April 2020.
  28. Grau-Carmona T, Bonet-Saris A, García-de-Lorenzo A, Sánchez Alvarez C, Rodríguez-Pozo A, Acosta-Escribano J et al. Influence of n-3 Polyunsaturated Fatty Acids Enriched Lipid Emulsions on Nosocomial Infections and Clinical Outcomes in Critically Ill Patients: ICU Lipids Study; Crit Care Med. 2015 Jan; 43(1):31-9.
  29. Barbosa VM, Miles EE, Calhua C, Lafuente E, Calder PC. Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial Critical Care 2010; 14:R5.
  30. Wichmann MW, Thul P, Czarnetzki H-D, Morlion BJ, Kemen M, Jauch K-W. Evaluation of clinical safety and beneficial effects of a fish oil containing lipid emulsion (Lipoplus, MLF541): data from a prospective, randomized, multicenter trial Critical Care Medicine 2007; 35(3):700-706.
  31. Zhang C, Li N, Wang X, Li G, Fan C, Li J. Influence of Lipoplus fat emulsion on postoperative nutritional status and early inflammatory response in patients with gastrointestinal malignancies. Zhonghua Wei Chang Wai Ke Za Zhi 2012; 15(5):448-51.

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